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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Membrane progesterone receptor ： ウィキペディア英語版 Membrane progesterone receptor Membrane progesterone receptors (mPRs) are a group of G protein-coupled receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Unlike the progesterone receptor (PR), a nuclear receptor which mediates its effects via genomic mechanisms, mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades.〔 The mPRs mediate important physiological functions in male and female reproductive tracts, liver, neuroendocrine tissues, and the immune system as well as in breast and ovarian cancer. The mPRs appear to be involved in the neuroprotective and antigonadotropic effects of progesterone and allopregnanolone.〔〔 The progesterone active metabolites 5α-dihydroprogesterone, also a progestogen, and allopregnanolone, which are positive allosteric modulators of the GABAA receptor, have been found to rapidly influence sexual receptivity and behavior in mice, actions that are GABAA receptor-dependent. These proteins are classified into three groups known as membrane progesterone receptors alpha, beta and gamma (mPR-alpha, mPR-beta PAQR8 and mPR-gamma). == mPR Subtypes == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Membrane progesterone receptor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.